The accelerator hypothesis cannot be tested using the type 2 diabetes gene, TCF7L2

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Prime suspect: the TCF7L2 gene and type 2 diabetes risk.

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Genetic variants in the gene encoding for transcription factor-7-like 2 (TCF7L2) have been associated with type 2 diabetes (T2D) and impaired beta cell function, but the mechanisms have remained unknown. We therefore studied prospectively the ability of common variants in TCF7L2 to predict future T2D and explored the mechanisms by which they would do this. Scandinavian subjects followed for up ...

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ژورنال

عنوان ژورنال: Diabetologia

سال: 2007

ISSN: 0012-186X,1432-0428

DOI: 10.1007/s00125-007-0725-x