The accelerator hypothesis cannot be tested using the type 2 diabetes gene, TCF7L2
نویسندگان
چکیده
منابع مشابه
Prime suspect: the TCF7L2 gene and type 2 diabetes risk.
Transcription factor-7-like 2 (TCF7L2) is the most important type 2 diabetes susceptibility gene identified to date, with common intronic variants strongly associated with diabetes in all major racial groups. This ubiquitous transcription factor in the Wnt signaling pathway was not previously known to be involved in glucose homeostasis, so defining the underlying mechanism(s) will provide new i...
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Genetic variants in the gene encoding for transcription factor-7-like 2 (TCF7L2) have been associated with type 2 diabetes (T2D) and impaired beta cell function, but the mechanisms have remained unknown. We therefore studied prospectively the ability of common variants in TCF7L2 to predict future T2D and explored the mechanisms by which they would do this. Scandinavian subjects followed for up ...
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Type 2 diabetes is associated with impaired insulin secretion. Both 1stand 2nd-phase insulin secretion are reduced, but the effect is particularly pronounced for the 1st phase. The processes culminating in impaired insulin secretion are not fully understood, but both genetic and environmental factors are thought to play a role. Over the past 2 years, genome-wide association scans have transform...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2007
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-007-0725-x